Integrins play a central role in mediating lymphocyte
adhesion to a number of surfaces. LFA-1 interacts with ICAMs
1-3 that are typically expressed on other immune system cells.
ICAM-4 also interacts with LFA-1, and is known to be
expressed on telencepahlic neurons.<p><p>VCAM-1 regulates
lymphocyte adhesion to activated endothelial cells via Very
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<bp:name rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of Apoptosis</bp:name>
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<bp:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A regulated balance between cell survival and apoptosis is essential for normal
development and homeostasis of multicellular organisms (see Matsuzawa, 2001). Defects in control of this balance may contribute to autoimmune disease, neurodegeneration and cancer. Protein ubiquitination and degradation is one of the major mechanisms that regulate apoptotic cell death (reviewed in Yang and Yu 2003).</bp:comment>
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<bp:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Authored: Jakobi, R, 2008-02-05 11:04:14</bp:comment>
<bp:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reviewed: Chang, E, 2008-05-21 00:05:41</bp:comment>
<bp:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Edited: Matthews, L, 2008-02-12 16:13:24</bp:comment>
<bp:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Edited: Matthews, L, 2008-06-12 00:23:53</bp:comment>
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